The London Telegraph is reporting that part of Obama’s overture to Hillary Clinton to support his candidacy will include a cabinet post, likely HHS:
The former First Lady would get the chance to pilot Mr Obama’s reforms of the American healthcare system if she agrees to clear the path to his nomination as Democratic presidential candidate.
Senior figures in the Obama camp have told Democrat colleagues that the offer to Mrs Clinton of a cabinet post as health secretary or to steer new legislation through the Senate will be a central element of their peace overtures to the New York senator.
My guess here is that you don’t leave the senate for HHS. To become the first female defense secretary (if my knowledge of history is holding up), perhaps. Treasury secretary, I could see that happening too. Not HHS, however.